Key result
In guinea-pig hepatocytes, the mean resting potential is -49.8 mV and is relatively insensitive to changes in extracellular potassium, sodium, or chloride concentrations.
Population
Pieces of guinea-pig liver with an intact capsule
Comparison
Changes in extracellular ion concentrations and… vs Normal resting conditions / Ringer solution
Design
Preclinical
Authors
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Hypothesis-generating for hepatocyte electrophysiology; requires human validation before any clinical extrapolation.
The resting transmembrane potential of guinea-pig hepatocytes is approximately -49.8 mV and is relatively insensitive to changes in extracellular potassium below 10 mM, with evidence suggesting an electrogenic ouabain-sensitive ion pump contributes to the potential.
Heller et al. (1974) studied this question. Extracellular ion concentration changes and metabolic poisons vs. Baseline/Normal Ringer solution was evaluated on Transmembrane resting potential (E). In guinea-pig hepatocytes, the mean resting potential is -49.8 mV and is relatively insensitive to changes in extracellular potassium, sodium, or chloride concentrations.
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