September 18, 2007Cardiovascular Research
Dynamic interactions of an intracellular Ca2+ clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function
Population
Sinoatrial nodal cells (cardiac pacemaker cells)
Design
Review
Authors
Discussion
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Implication
Challenges membrane-only pacemaker models; leaves open Ca2+-clock modulation for sinus node therapies.
Structured PICO
P
Population
Sinoatrial nodal cells (cardiac pacemaker cells)
This review establishes a novel paradigm for cardiac pacemaker function, highlighting the essential role of the intracellular Ca2+ clock in initiating and regulating the heartbeat.
Cite This Study
Maltsev et al. (2007) studied this question.