The Missing Link in the Mystery of Normal Automaticity of Cardiac Pacemaker Cells
Population
Cardiac pacemaker cells (sinoatrial cells)
Design
Review
Authors
Discussion
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Member takes
Implication
Integrates Ca2+ clock with NCX in pacemaker chronotropy; leaves open translation to clinical rate disorders.
Structured PICO
P
Population
Cardiac pacemaker cells (sinoatrial cells)
The normal automaticity of cardiac pacemaker cells relies on a precisely regulated intracellular Ca2+ clock that integrates with membrane ion channels to rhythmically ignite action potentials.
Cite This Study
Lakatta et al. (2008) studied this question.