Population
PS2 knockout (PS2KO) mice and HEK-293 cells
Comparison
Presenilin 2 (PS2) knockout vs Littermate controls
Design
Preclinical
Authors
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Does not support clinical targeting of presenilin 2; leaves open its role in human excitation-contraction coupling.
Presenilin 2 regulates cardiac systolic function and excitation-contraction coupling through interaction with the ryanodine receptor (RyR2).
Takeda et al. (2005) studied this question.
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