Population
Transgenic mice and dissociated cardiomyocytes
Comparison
Cardiac-specific overexpression of L112-sorcin… vs Control cells and mice with cardiac-specific…
Design
Preclinical
Authors
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Sorcin mutation effects on myocyte calcium handling are hypothesis-generating; human relevance and therapeutic targeting remain unproven.
The L112-sorcin mutation alters cardiac calcium regulation, highlighting sorcin's role in excitation-contraction coupling, though it does not independently cause hypertension or hypertrophy in mice.
Collis et al. (2006) studied this question.
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