Why the study?
Does adenovirus-mediated sorcin overexpression alter excitation-contraction coupling in isolated rabbit cardiomyocytes?
Does adenovirus-mediated sorcin overexpression alter excitation-contraction coupling in isolated rabbit cardiomyocytes?
Sorcin overexpression in rabbit cardiomyocytes decreases Ca2+-transient amplitude primarily by lowering SR Ca2+ content via increased NCX activity, and alters Ca2+ sparks, indicating an effect on the ryanodine receptor.
No takes yet. Share an insight, caveat, or question.
Sorcin overexpression may impair myocyte contractility in rabbits; hypothesis-generating for human Ca2+ handling and therapeutic targeting.
Seidler et al. (2003) studied this question.