Why the study?
The relevance of Sorbs2 to adult-onset cardiomyopathies and the mechanisms underlying lethal arrhythmogenic cardiomyopathy in global knockout mice remained underexplored and unclear.
Does cardiomyocyte-specific knockout of Sorbs2 cause dilated cardiomyopathy and heart failure in mice?
Population
Sorbs2 cardiomyocyte-specific knockout (Sorbs2-cKO) mice and human bioinformatic datasets
Comparison
Sorbs2 cardiomyocyte-specific knockout vs controls
Design
Preclinical animal model and bioinformatic association study
Follow-up
About 1 year
Authors
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Cardiomyocyte Sorbs2 loss causes dilated cardiomyopathy in mice; leaves open its role in human adult-onset heart failure.
Does cardiomyocyte-specific knockout of Sorbs2 cause dilated cardiomyopathy and heart failure in mice?
Sorbs2 is essential for maintaining structural integrity in cardiomyocytes, and its loss leads to defective microtubule polymerization, dilated cardiomyopathy, and heart failure.
McLendon et al. (2022) studied this question.
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