Key result
Elastase incubation abolished structural and mechanical differences between mesenteric resistance arteries from spontaneously hypertensive and normotensive rats.
Why the study?
Does elastin degradation reverse structural and mechanical alterations in mesenteric resistance arteries of spontaneously hypertensive rats?
Population
Mesenteric resistance arteries from spontaneously hypertensive rats and normotensive Wistar Kyoto rats
Comparison
Elastase incubation vs Vessels before elastase incubation, and WKY…
Design
Preclinical
Authors
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Supports elastin degradation as modulator of hypertensive resistance artery remodeling; leaves open translation from rodent models to patients.
Does elastin degradation reverse structural and mechanical alterations in mesenteric resistance arteries of spontaneously hypertensive rats?
Elastin restructuring within the internal elastic lamina plays a central role in small artery remodeling and increased stiffness in hypertension, which can be reversed by elastin degradation.
Briones et al. (2003) studied Hypertension. Elastase incubation vs. Before elastase incubation / WKY rats was evaluated on Vascular dimensions and mechanical properties (structure and mechanics of MRA). Elastase incubation abolished structural and mechanical differences between mesenteric resistance arteries from spontaneously hypertensive and normotensive rats.
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