Key result
Longitudinal stretch >> 20% optimized vasoconstrictor responses to noradrenaline and phenylephrine in isolated rat third order mesenteric arteries, but did not affect other studied arteries.
Population
Isolated, pressurised arteries from the rat mesentery, rat mid-cerebral and human subcutaneous vascular beds
Design
Preclinical
Authors
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Does not support changes to clinical vascular assessment; leaves open optimal stretch for other arteries or species in pharmacological studies.
Longitudinal stretch >20% is an important methodological consideration that optimizes experimental conditions for pharmacological studies in isobaric-mounted rat third order mesenteric arteries.
Coats et al. (1999) studied Isolated resistance arteries. Longitudinal stretch was evaluated on Vasoreactivity (vasoconstrictor responses to noradrenaline and phenylephrine). Longitudinal stretch >> 20% optimized vasoconstrictor responses to noradrenaline and phenylephrine in isolated rat third order mesenteric arteries, but did not affect other studied arteries.
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