Why the study?
Does axial stretch modify the sensitivity of porcine coronary arteries to vasoconstrictors via a protein kinase C-dependent mechanism?
Population
Endothelium-denuded cylindrical segments from large porcine coronary arteries
Comparison
20% axial stretch at a pressure of 60 mmHg, with… vs Unstretched segments or segments without…
Design
Preclinical
Authors
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Axial stretch may heighten porcine coronary vasoconstrictor sensitivity via PKC; hypothesis-generating for human vasoreactivity with no current clinical implications.
Does axial stretch modify the sensitivity of porcine coronary arteries to vasoconstrictors via a protein kinase C-dependent mechanism?
Axial stretch enhances the sensitivity of large porcine coronary arteries to vasoconstrictors through a protein kinase C-dependent mechanism.
Tankó et al. (2001) studied this question.
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