Key result
Spontaneously hypertensive rats exhibited hyperplasia in mesenteric resistance vessels, with a greater number of cells per unit length compared to Wistar-Kyoto rats (10.4 vs 7.4/micron; P<0.05).
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Animal data on hyperplasia in hypertensive resistance vessels warrant human mechanistic studies; should not yet influence clinical practice.
Absolute Event Rate: 10.4% vs 7.4%
p-value: p=<0.05
Mulvany et al. (1985) studied Hypertension (n=20). Spontaneous hypertension vs. Wistar-Kyoto rats was evaluated on Number of cells per unit length (p=<0.05). Spontaneously hypertensive rats exhibited hyperplasia in mesenteric resistance vessels, with a greater number of cells per unit length compared to Wistar-Kyoto rats (10.4 vs 7.4/micron; P<0.05).
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