Key result
This review highlights the critical role of L-type voltage-dependent calcium channels and their auxiliary subunits in normal cardiac function, excitation-contraction coupling, and the progression of heart failure and arrhythmias.
Design
Review
Authors
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Emphasizes LTCCs in HF pathogenesis; leaves open targeted therapeutic trials.
This review highlights the fundamental role of calcium and L-type calcium channels in normal cardiac function and the pathogenesis of cardiac diseases such as hypertrophy and heart failure.
Ilona Bódi (2005) conducted a review in Cardiac disease (hypertrophy, heart failure, arrhythmias). L-type voltage-dependent Ca2+ channels (L-VDCC) was evaluated. This review highlights the critical role of L-type voltage-dependent calcium channels and their auxiliary subunits in normal cardiac function, excitation-contraction coupling, and the progression of heart failure and arrhythmias.
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