Key result
Current cigarette smoking increased the risk of aneurysmal subarachnoid hemorrhage significantly more in women (HR 8.9; 95% CI 4.7-17.0) than in men (HR 2.8; 95% CI 1.3-6.1).
Why the study?
Are there sex differences in the major established risk factors for aneurysmal subarachnoid hemorrhage?
Population
92,462 participants of the Nord-Trøndelag and the Tromsø Health Studies in Norway
Comparison
Current cigarette smoking, hypertension, and… vs Nonsmokers; Men vs Women
Design
Cohort
Follow-up
1,002,148 person-years at risk
Authors
Loading...
May support sex-specific smoking cessation emphasis in aSAH prevention; leaves open causal mechanisms and generalizability.
Cohort (n=92,462)
Yes
Are there sex differences in the major established risk factors for aneurysmal subarachnoid hemorrhage?
Hazard Ratio: 8.9 (95% CI 4.7–17)
Current cigarette smoking confers a significantly higher risk of aneurysmal subarachnoid hemorrhage in women compared to men, potentially explaining the gender gap in aSAH incidence.
Lindekleiv et al. (2011) conducted a cohort in aneurysmal subarachnoid hemorrhage (n=92,462). Current cigarette smoking vs. Nonsmokers was evaluated on aneurysmal subarachnoid hemorrhage (aSAH) (HR 8.9, 95% CI 4.7-17.0). Current cigarette smoking increased the risk of aneurysmal subarachnoid hemorrhage significantly more in women (HR 8.9; 95% CI 4.7-17.0) than in men (HR 2.8; 95% CI 1.3-6.1).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: