Why the study?
Does isotonic expansion of extracellular fluid volume improve the postoperative limitation in sodium excretion in surgical patients?
Population
Surgical patients in the immediate postoperative state, including a patient with Addison's disease
Comparison
Isotonic expansion of the extracellular fluid… vs Standard postoperative state without isotonic…
Design
Other
Follow-up
Immediate postoperative period
Authors
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Supports volume-guided fluid strategies in surgical care; leaves open validation in contemporary randomized trials.
Does isotonic expansion of extracellular fluid volume improve the postoperative limitation in sodium excretion in surgical patients?
Postoperative sodium retention is driven by contraction of the effective extracellular fluid volume rather than increased adrenal cortical hormone secretion, and can be corrected by isotonic fluid expansion.
Randall et al. (1958) studied this question.
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