Key result
Okadaic acid promotes high-activity gating mode ('mode 2') via a type 2A-like phosphatase, while calyculin A increases channel availability via a type 1-like phosphatase.
Distinct protein phosphatase subtypes (type 1-like and type 2A-like) differentially regulate the availability and gating modes of cardiac L-type calcium channels.
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Animal data support distinct phosphatase subtype control of cardiac L-type Ca channels; leaves open human translation and therapeutic relevance.
Wiechen et al. (1995) studied this question. Phosphatase inhibitors (okadaic acid and calyculin A) vs. Norokadaone was evaluated on Effects on single guinea-pig ventricular L-type Ca2+ channels. Okadaic acid promotes high-activity gating mode ('mode 2') via a type 2A-like phosphatase, while calyculin A increases channel availability via a type 1-like phosphatase.
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