Key result
Okadaic acid increased force of contraction to 175% of predrug value and increased phosphorylation of phospholamban and troponin inhibitor to 325% and 284% of control in guinea pig cardiac models.
Okadaic acid exerts a positive inotropic effect in cardiac preparations, likely mediated by increasing the phosphorylation state of proteins including PLB, TnI, and a 23-kDa protein.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating for phosphatase inhibition as inotropy target; leaves open clinical translation from guinea pig models.
Neumann et al. (1993) studied this question. Okadaic acid vs. predrug value / control was evaluated on Force of contraction, Ca(2+)-channel currents, phosphatase activity, and protein phosphorylation. Okadaic acid increased force of contraction to 175% of predrug value and increased phosphorylation of phospholamban and troponin inhibitor to 325% and 284% of control in guinea pig cardiac models.