Why the study?
Does acidosis alter the phosphorylation of phospholamban and troponin I in rat cardiac muscle?
Population
Langendorff-perfused rat hearts labeled with 32P
Comparison
Acidosis in the absence and presence of… vs Control in the absence and presence of…
Design
Preclinical
Authors
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No immediate clinical implications from rat data; leaves open mechanistic links between acidosis, phosphoproteins, and human cardiac dysfunction.
Does acidosis alter the phosphorylation of phospholamban and troponin I in rat cardiac muscle?
Acidosis alters the phosphorylation of phospholamban and troponin I in rat cardiac muscle, which may partly explain the acidosis-induced changes in sarcoplasmic reticulum and myofilament function.
Vittone et al. (1996) studied this question.
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