Key result
Changes in blood flow to the inner renal medulla can have a major effect on sodium and water homeostasis and on the long-term control of arterial blood pressure.
Population
Humans and experimental animals (including spontaneously hypertensive rats and normal Sprague-Dawley rats)
Design
Review
Authors
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Inner medullary flow merits mechanistic study in hypertension; leaves open its value as a therapeutic target.
This review highlights that despite comprising less than 1% of total renal blood flow, the inner renal medulla plays a critical role in long-term arterial pressure control and the pathogenesis of hypertension.
Cowley et al. (1995) conducted a review in Hypertension. Renal medullary blood flow changes was evaluated. Changes in blood flow to the inner renal medulla can have a major effect on sodium and water homeostasis and on the long-term control of arterial blood pressure.
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