Population
Spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats
Comparison
Alterations in renal perfusion pressure… vs Normotensive WKY rats or baseline conditions
Design
Preclinical
Authors
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Supports renal hemodynamics in hypertension models; leaves open nisoldipine translation to patients.
Alterations in renal medullary hemodynamics significantly impact the pressure-natriuresis relationship and arterial pressure regulation in hypertension.
Cowley et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: