January 1, 1990Clinical and Experimental Hypertension

Role of Intrarenal Renin-Angiotensin System on Pressure-Natriuresis in Spontaneously Hypertensive Rats

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Population

Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY)

Comparison

Intrarenal renin-angiotensin system blockade… vs Without intrarenal RAS blockade, and comparison…

Design

Preclinical

Authors

TTTsuneo TakenakaInternational University of Health and Welfare HSHiromichi SuzukiYamagata University TFTomohiro FurukawaNational Agriculture and Food Research Organization

Discussion

Member takes

Implication

Intrarenal RAS contributes to pressure-natriuresis resetting in SHR; leaves open targeted inhibition as a strategy for human hypertension.

Structured PICO

Population

Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY)

Intervention

Intrarenal renin-angiotensin system (RAS) blockade using MK-422 (0.3 ug/kg/min), Thi5,8, D-Phe7-bradykinin (50 micrograms/kg/min), Sar1, Ile8-angiotensin (70 ng/kg/min), or angiotensin I (10 ng/kg/min)

Comparator

Without intrarenal RAS blockade, and comparison between SHR and WKY strains

Outcome

Pressure-natriuresis relationship (sodium excretion at a given pressure)surrogate

Alteration of the intrarenal renin-angiotensin system in spontaneously hypertensive rats contributes to resetting the pressure-natriuresis relationship.

Cite This Study

Takenaka et al. (1990) studied this question.

synapsesocial.com/papers/6a856bcf425e2f70a467175a https://doi.org/10.3109/10641969009073525

Topics

Hypertension management

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Implication

Intrarenal RAS contributes to pressure-natriuresis resetting in SHR; leaves open targeted inhibition as a strategy for human hypertension.

Role of Intrarenal Renin-Angiotensin System on Pressure-Natriuresis in Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Role of Intrarenal Renin-Angiotensin System on Pressure-Natriuresis in Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider