Key result
Emma-fApEn combined with random forest machine learning achieved an accuracy of 96.67% in OSA screening and 91.67% in severe OSA screening.
Why the study?
Obstructive sleep apnea is associated with autonomic nervous system dysfunction, motivating the evaluation of Emma-fApEn to assess sympathetic tension limits via heart rate variability for disease severity screening.
Does Emma-fApEn analysis of heart rate variability accurately screen for obstructive sleep apnea?
Observational (n=60)
Does Emma-fApEn analysis of heart rate variability accurately screen for obstructive sleep apnea?
Emma-fApEn analysis of heart rate variability provides high accuracy for the preliminary screening and severity assessment of obstructive sleep apnea.
May support HRV-based OSA screening tools; leaves open prospective validation in larger cohorts.
OBJECTIVE: Obstructive sleep apnea (OSA) is a respiratory disease associated with autonomic nervous system dysfunction. As a novel method for analyzing OSA depending on heart rate variability, fuzzy approximate entropy of extrema based on multiple moving averages (Emma-fApEn) can effectively assess the sympathetic tension limits, thereby realizing a good performance in the disease severity screening. METHOD: Sixty 6-h electrocardiogram recordings (20 healthy, 16 mild/moderate OSA and 34 severe OSA) from the PhysioNet database were used in this study. The performances of minima of Emma-fApEn (fApEn-minima), maxima of Emma-fApEn (fApEn-maxima) and classic time-frequency domain indices for each recording were assessed by significance analysis, correlation analysis, parameter optimization and OSA screening. RESULTS: fApEn-minima and fApEn-maxima had significant differences between the severe OSA group and the other two groups, while the mean value (Mean) and the ratio of low-frequency power and high-frequency power (LH) could significantly differentiate OSA recordings from healthy recordings. The correlation coefficient between fApEn-minima and apnea-hypopnea index was the highest (|R| = 0.705). Machine learning methods were used to evaluate the performances of the above four indices. Random forest (RF) achieved the highest accuracy of 96.67% in OSA screening and 91.67% in severe OSA screening, with a good balance in both. CONCLUSION: Emma-fApEn may be used as a simple preliminary detection tool to assess the severity of OSA prior to polysomnography analysis.
No takes yet. Share an insight, caveat, or question.
Weng et al. (2022) conducted an observational in Obstructive sleep apnea (OSA) (n=60). Fuzzy approximate entropy of extrema based on multiple moving averages (Emma-fApEn) vs. Classic time-frequency domain indices was evaluated on OSA screening accuracy using random forest. Emma-fApEn combined with random forest machine learning achieved an accuracy of 96.67% in OSA screening and 91.67% in severe OSA screening.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: