Key result
The minor alleles G and T of ADIPOQ polymorphisms -11377C/G and +276G/T were independent predictors of adiponectin levels in patients with resistant hypertension (p=0.03 and p=0.04, respectively).
Why the study?
Do ADIPOQ -11377C/G and +276G/T polymorphisms affect adiponectin levels in patients with resistant hypertension?
Cross-Sectional (n=109)
Do ADIPOQ -11377C/G and +276G/T polymorphisms affect adiponectin levels in patients with resistant hypertension?
Effect estimate: β-coefficient -0.14 for G allele and 0.12 for T allele
p-value: p=0.03 for G allele; 0.04 for T allele
The -11377C/G and +276G/T SNPs in the ADIPOQ gene are independent predictors of adiponectin levels in individuals with resistant hypertension, though they do not affect blood pressure or target organ damage.
No immediate change to resistant hypertension management; leaves open ADIPOQ genotyping utility in larger cohorts.
Resistant hypertension (RHTN) is a multifactorial and polygenic disease, frequently associated with obesity. Low plasma adiponectin levels, a hormone produced by the adipose tissue, were associated with RHTN. Single nucleotide polymorphisms (SNPs) -11377C/G (rs266729) and +276G/T (rs1501299) in ADIPOQ (adiponectin gene) were associated with hypertension. This study evaluated the association between two SNPs (-11377C/G and +276G/T) and adiponectin levels in RHTN. This study comprised 109 patients with RHTN genotyped for both polymorphisms. A cross-sectional study was designed to compare features of CC homozygous versus G allele carriers for -11377C/G and GG homozygous versus T allele carriers for +276G/T. Office and ambulatory BP measurements were similar among genotypes subgroups in both SNPs as well as the markers of target organ damage (arterial stiffness, left ventricular mass index and microalbuminuria). Adiponectin concentrations were significantly higher in CC compared to G carrier for -11377C/G (CC:7.0 (4.0-10.2) versus G allele:5.5 (2.5-7.9), p = 0.04) and lower in GG compared to T carrier for +276G/T (GG:5.3 (2.3-7.7) versus T allele:7.1 (3.6-10.5), p = 0.04). Adjusting for systolic ambulatory BP, body mass index, age, gender, race and presence of type 2 diabetes, multiple linear regression analyses revealed that the minor alleles G (β-coefficient= -0.14, SE=0.07, p = 0.03) and T (β-coefficient=0.12, SE=0.06, p = 0.04) were independent predictors of adiponectin. The -11377C/G and +276G/T SNPs in ADIPOQ were associated with adiponectin levels in RHTN individuals.
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Faria et al. (2014) conducted a cross-sectional in Resistant hypertension (RHTN) (n=109). ADIPOQ polymorphisms (-11377C/G and +276G/T) vs. CC homozygous vs G allele carriers for -11377C/G and GG homozygous vs T allele carriers for +276G/T was evaluated on Adiponectin concentrations (β-coefficient -0.14 for G allele and 0.12 for T allele, p=0.03 for G allele; 0.04 for T allele). The minor alleles G and T of ADIPOQ polymorphisms -11377C/G and +276G/T were independent predictors of adiponectin levels in patients with resistant hypertension (p=0.03 and p=0.04, respectively).
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