Key result
The ACE Ins/Del polymorphism was associated with hypertension in men >40 years old (P<0.05), and the APOB EcoRI polymorphism was associated with LDL-C variation (P<0.05).
Why the study?
Are polymorphisms in the ACE, APOB, and APOE genes associated with hypertension and variations in lipid serum levels in Afro-Brazilians with a familial history of CAD?
Observational (n=184)
Are polymorphisms in the ACE, APOB, and APOE genes associated with hypertension and variations in lipid serum levels in Afro-Brazilians with a familial history of CAD?
p-value: p=<0.05
In Afro-Brazilians with a family history of CAD, the ACE Ins/Del polymorphism is associated with hypertension, and the APOB EcoRI polymorphism is associated with LDL-C variation.
Should not change practice; leaves open causal and predictive roles pending longitudinal confirmation in Afro-Brazilians.
Associations of polymorphisms in the angiotensin I-converting enzyme (ACE), apolipoprotein B (APOB) and apolipoprotein E (APOE) genes with hypertension and variations in lipid serum levels were evaluated in 184 Afro-Brazilians with a familial history of coronary artery disease (CAD). ACE (Ins/Del) and APOB (Ins/Del, XbaI, and EcoRI) and APOE (HhaI) polymorphisms were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses on agarose, and polyacrylamide gel electrophoresis. Serum lipids were measured by means of routine enzymatic assays. The results showed a high frequency of hypertension (44%) in Afro-Brazilians that was increased in subjects >40 years old and those with a blood mass index (BMI) higher than 25 kg/m(2) (P<0.001). The ACE Del allele was associated with hypertension in men >40 years old (P<0.05). APOE (HhaI) and APOB (XbaI and Ins/Del) polymorphisms were not associated with hypertension or variations in serum concentrations of lipids, while subjects with the APOB E- allele had higher low-density lipoprotein cholesterol (LDL-C) levels than E+ carriers (P<0.05). These results suggest that ACE Ins/Del polymorphism is associated with hypertension, and APOB EcoRI polymorphism is associated with LDL-C variation in Afro-Brazilians.
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Sakuma et al. (2004) conducted an observational in Familial history of coronary artery disease (n=184). ACE, APOB, and APOE gene polymorphisms vs. Absence of specific polymorphisms was evaluated on Hypertension and variations in lipid serum levels (p=<0.05). The ACE Ins/Del polymorphism was associated with hypertension in men >40 years old (P<0.05), and the APOB EcoRI polymorphism was associated with LDL-C variation (P<0.05).
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