Key result
Higher plasma renin levels were independently associated with increased odds of prevalent cardiovascular disease (OR 1.37) and greater atherosclerotic burden in subjects with and without type 2 diabetes.
Why the study?
Are plasma renin levels associated with atherosclerotic burden in subjects with and without type 2 diabetes?
Population
1,705 subjects, comprising 985 with type 2 diabetes and 515 without T2D from the SUMMIT study cohort, plus…
Design
Cross-sectional
Authors
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Higher renin associated with CVD burden in T2D and non-T2D; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=1,705)
Yes
Are plasma renin levels associated with atherosclerotic burden in subjects with and without type 2 diabetes?
Odds Ratio: 1.37 (95% CI 1.22–1.55)
p-value: p=9.5E-08
Plasma renin levels are independently associated with atherosclerotic burden and prevalent cardiovascular disease in subjects with and without type 2 diabetes, suggesting systemic RAAS activation contributes to vascular complications.
Gonçalves et al. (2016) conducted a cross-sectional in Type 2 diabetes and cardiovascular disease (n=1,705). Plasma renin levels vs. Lower plasma renin levels was evaluated on Prevalent cardiovascular disease (CVD) risk per log2 increase in plasma renin levels (OR 1.37, 95% CI 1.22-1.55, p=9.5E-08). Higher plasma renin levels were independently associated with increased odds of prevalent cardiovascular disease (OR 1.37) and greater atherosclerotic burden in subjects with and without type 2 diabetes.
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