Key result
Adipocyte-specific angiotensinogen deficiency in mice significantly reduced systolic blood pressure compared with controls (110 ± 2 vs 117 ± 2 mmHg; P<0.05).
Why the study?
Does adipocyte-specific deficiency of angiotensinogen reduce plasma AGT concentration and systolic blood pressure in mice?
Population
Mice with adipocyte-specific angiotensinogen deficiency (Agt) generated by breeding Agt mice with transgenic…
Comparison
Adipocyte-specific deficiency of angiotensinogen… vs Control mice (Agt(fl/fl))
Design
Preclinical
Follow-up
2 or 12 months
Authors
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Adipocyte AGT contributes to SBP regulation in mice; extends RAS source knowledge but leaves open human translation.
Does adipocyte-specific deficiency of angiotensinogen reduce plasma AGT concentration and systolic blood pressure in mice?
Absolute Event Rate: 110% vs 117%
p-value: p=<0.05
Adipocyte-derived angiotensinogen contributes significantly to the systemic renin-angiotensin system and the regulation of systolic blood pressure in mice.
Yiannikouris et al. (2011) studied this question. Adipocyte-specific angiotensinogen (AGT) deficiency vs. Control mice (Agt(fl/fl)) was evaluated on Systolic blood pressure (p=<0.05). Adipocyte-specific angiotensinogen deficiency in mice significantly reduced systolic blood pressure compared with controls (110 ± 2 vs 117 ± 2 mmHg; P<0.05).
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