Why the study?
Does adipose-derived angiotensinogen affect adipose tissue development and systemic blood pressure in mice?
Population
Transgenic mice (wild-type and hypotensive AGT-deficient mice)
Comparison
Targeted expression of rat agt cDNA in adipose… vs Wild-type mice and AGT-deficient mice
Design
Preclinical
Authors
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Adipose AGT may regulate BP in mice; hypothesis-generating for obesity-hypertension mechanisms and requires human validation.
Does adipose-derived angiotensinogen affect adipose tissue development and systemic blood pressure in mice?
Adipose tissue-derived angiotensinogen contributes to systemic circulating AGT levels, regulates blood pressure, and promotes local adipose tissue development, suggesting a mechanism for obesity-related hypertension.
Massiéra et al. (2001) studied this question.
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