Why the study?
Does hepatocyte AGT deficiency reduce blood pressure and plasma angiotensin concentrations in lean and obese male mice?
Population
Male Agt(fl/fl) or hepatocyte AGT-deficient male mice (Agt(Alb)) fed a low-fat or high-fat diet
Comparison
Hepatocyte AGT deficiency (Agt(Alb) mice) vs Agt(fl/fl) control mice
Design
Preclinical
Follow-up
16 weeks
Authors
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Hepatocyte AGT merits exploration as an antihypertensive target; leaves open translation to human hypertension.
Does hepatocyte AGT deficiency reduce blood pressure and plasma angiotensin concentrations in lean and obese male mice?
Hepatocytes are the predominant source of systemic AGT, and hepatocyte AGT deficiency markedly reduces blood pressure in both lean and obese mice.
Yiannikouris et al. (2015) studied this question.
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