Population
Normal mice and transgenic mice expressing the human angiotensinogen gene under the control of its own…
Comparison
High-fat diet (45% kcal) for 10 and 20 weeks vs Normal chow (10% kcal) for 10 and 20 weeks
Design
Preclinical
Follow-up
10 and 20 weeks
Authors
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Supports visceral AGT upregulation as a diet-obesity link; hypothesis-generating and requires human confirmation before clinical relevance.
High-fat diet-induced obesity upregulates angiotensinogen gene expression specifically in visceral adipose tissue, highlighting a depot-specific mechanism linking obesity and the renin-angiotensin system.
Rahmouni et al. (2004) studied this question.
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