January 1, 1989Endocrinology
Hybridization in Situ Studies of Angiotensinogen Gene Expression in Rat Adrenal and Lung*
Why the study?
Does hormone treatment alter the cellular localization of angiotensinogen mRNA in rat adrenal and lung tissues?
Population
Rats (control and hormone-treated)
Comparison
Combination of dexamethasone, ethynylestradiol… vs Control rats
Design
Preclinical
Authors
Discussion
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Implication
Supports local angiotensin formation in rat tissues; extends preclinical evidence but leaves open human relevance.
Structured PICO
Does hormone treatment alter the cellular localization of angiotensinogen mRNA in rat adrenal and lung tissues?
P
Population
Rats (control and hormone-treated)
I
Intervention
Combination of dexamethasone, ethynylestradiol, and T3
C
Comparator
Control rats
O
Outcome
Cellular localization of angiotensinogen mRNA in adrenal and lung tissuessurrogate
Angiotensinogen mRNA is localized in specific fibroblast-like cells and brown adipose tissue in rat adrenal and lung, supporting local tissue angiotensin formation independent of the circulating renin-angiotensin system.
Cite This Study
Campbell et al. (1989) studied this question.