Key result
The Elecsys Troponin T third generation assay using recombinant human cardiac troponin T standard eliminates linearity problems and demonstrates high precision.
The use of recombinant human cardiac troponin T as standard material provides reproducible and reliable standardization for troponin T assays, resolving previous linearity issues.
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May enhance troponin T assay reliability in labs; leaves open effects on diagnostic decisions or outcomes.
The Elecsys Troponin T third generation assay uses recombinant human cardiac troponin T as standard material. The new assay has a linear calibration curve. Thus, linearity problems observed with the second generation assay have been eliminated. The assay has high precision, especially at the low end of measuring range (inter-assay CV < 10% at 0.1 microgram/L). The new standardization does not change the cut-off value of 0.1 microgram/L. The use of recombinant human cardiac troponin T as standard material enables a reproducible and reliable standardization of troponin T assays.
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Hallermayer et al. (1999) studied this question. Elecsys Troponin T third generation assay vs. Second generation assay was evaluated on Assay linearity and precision. The Elecsys Troponin T third generation assay using recombinant human cardiac troponin T standard eliminates linearity problems and demonstrates high precision.
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