What question did this study set out to answer?

This study investigates how local reductions in pressure affect the structure and mechanical properties of cerebral arterioles in different rat models.

February 1, 1991Circulation ResearchOpen Access

Effects of local reduction in pressure on distensibility and composition of cerebral arterioles.

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Why the study?

Does local reduction in pressure via carotid clipping affect distensibility and composition of cerebral arterioles in normotensive and hypertensive rats?

Population

Normotensive Wistar-Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP)

Comparison

Clipping of one carotid artery at 1 month of age vs Sham cerebral hemisphere (unclipped side)

Design

Preclinical

Follow-up

Examined at 10-12 months of age

Authors

GBGary L. BaumbachABB (United States)JSJ E SiemsUniversity of Iowa DHDonald D. HeistadOregon National Primate Research Center

Discussion

Member takes

Implication

Local pressure reduction may attenuate cerebral arteriolar hypertrophy in hypertensive rats; extends experimental models but leaves open clinical translation.

Key Points

This study investigates how local reductions in pressure affect the structure and mechanical properties of cerebral arterioles in different rat models.
Normotensive Wistar-Kyoto rats and stroke-prone spontaneously hypertensive rats received carotid artery clipping at 1 month of age.
In vivo mechanics of pial arterioles were assessed at 10-12 months using bilateral craniotomies and measurements of pressure and diameter.
Point counting stereology quantified arteriolar wall components pre- and post-EDTA administration.
Mean pressure in clipped arterioles was significantly lower in WKY (Pm 63 mm Hg vs. 73 mm Hg) and SHRSP (Pm 94 mm Hg vs. 110 mm Hg) with p<0.05.
Cross-sectional area of arteriolar wall was less in clipped than sham arterioles in both WKY and SHRSP (1,403 microns2 vs 1,683 microns2 in WKY).
Clipped SHRSP showed decreased passive distensibility compared to WKY, indicating altered vascular characteristics.

Structured PICO

Does local reduction in pressure via carotid clipping affect distensibility and composition of cerebral arterioles in normotensive and hypertensive rats?

Population

Normotensive Wistar-Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP)

Intervention

Clipping of one carotid artery at 1 month of age

Comparator

Sham cerebral hemisphere (unclipped side)

Outcome

Mechanics of pial arterioles (stress-strain relations, pressure, diameter, cross-sectional area) and composition of the arteriolar wallsurrogate

Reduction of pial arteriolar pressure via carotid clipping prevents cerebral vascular hypertrophy and attenuates increases in passive distensibility in stroke-prone spontaneously hypertensive rats.

Cite This Study

Baumbach et al. (1991) studied this question.

synapsesocial.com/papers/6a1fea83d4e6d3589704aa17 https://doi.org/10.1161/01.res.68.2.338

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Implication

Local pressure reduction may attenuate cerebral arteriolar hypertrophy in hypertensive rats; extends experimental models but leaves open clinical translation.

Effects of local reduction in pressure on distensibility and composition of cerebral arterioles.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of local reduction in pressure on distensibility and composition of cerebral arterioles.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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