What question did this study set out to answer?

This study aims to explore if increases in pulse pressure lead to hypertrophy of cerebral arterioles, independent of mean pressure changes.

February 1, 1996Hypertension

Effects of Increased Pulse Pressure on Cerebral Arterioles

Q: What is the clinical evidence from this study?

Study design: Other. Population: Increased pulse pressure and cerebral arteriole hypertrophy. Intervention: Arteriovenous fistula vs. Abdominal aorta exposure without fistula and unilateral carotid clipping. Primary outcome: Cross-sectional area of the vessel wall in sham pial arterioles (microns^2) (p=<.05).

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Key result

In Sprague-Dawley rats, an arteriovenous fistula increased pulse pressure and cross-sectional area of pial arterioles compared to controls (1468 vs 1129 microns^2; P<0.05).

Why the study?

Does increased pulse pressure produce hypertrophy of cerebral arterioles in a rat model?

Population

Sprague-Dawley rats at 1 month of age

Comparison

Creation of an arteriovenous fistula and… vs Exposure of the abdominal aorta without fistula…

Design

Preclinical

Follow-up

5 months (from 1 month to 6 months of age)

Authors

GBGary L. BaumbachABB (United States)

Discussion

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Implication

Hypothesis-generating for pulse pressure effects on cerebral arterioles in rats; leaves open relevance to human hypertension.

Key Points

This study aims to explore if increases in pulse pressure lead to hypertrophy of cerebral arterioles, independent of mean pressure changes.
Sprague-Dawley rats underwent arteriovenous fistula creation and carotid artery clipping at 1 month of age.
Pial arterioles were examined in vivo at 6 months using pressure and diameter measurements, and wall components were quantified with point counting stereology.
Changes in stress-strain relationships were assessed during maximal dilation of the arterioles.
Increased pulse pressure in arteriovenous fistula rats: cross-sectional area 1468 +/- 100 microns² (P < .05), compared to 1129 +/- 104 microns² in controls.
Systolic pressures were comparable, but diastolic pressure was lower in arteriovenous fistula rats at 43 +/- 2 mm Hg versus 53 +/- 3 mm Hg in controls.
Stress-strain curves indicate enhanced passive distensibility in arteriovenous fistula rats.

Structured PICO

Does increased pulse pressure produce hypertrophy of cerebral arterioles in a rat model?

Population

Sprague-Dawley rats undergoing creation of an arteriovenous fistula and unilateral carotid clipping at 1 month of age, examined at 6 months of age.

Intervention

Creation of an arteriovenous fistula and clipping of one carotid artery

Comparator

Exposure of the abdominal aorta without fistula production and unilateral carotid clipping

Outcome

Hypertrophy of cerebral arterioles (cross-sectional area of the vessel wall and pulse pressure)surrogate

Main Result

Absolute Event Rate: 1468% vs 1129%

p-value: p=<.05

Increases in pulse pressure, even without increases in mean pressure, are sufficient to produce hypertrophy of cerebral arterioles in a rat model.

Cite This Study

Gary L. Baumbach (1996) studied Increased pulse pressure and cerebral arteriole hypertrophy. Arteriovenous fistula vs. Abdominal aorta exposure without fistula and unilateral carotid clipping was evaluated on Cross-sectional area of the vessel wall in sham pial arterioles (microns^2) (p=<.05). In Sprague-Dawley rats, an arteriovenous fistula increased pulse pressure and cross-sectional area of pial arterioles compared to controls (1468 vs 1129 microns^2; P<0.05).

synapsesocial.com/papers/6a632735cd7899abd6b6f312 https://doi.org/10.1161/01.hyp.27.2.159

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Effects of Increased Pulse Pressure on Cerebral Arterioles

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Effects of Increased Pulse Pressure on Cerebral Arterioles

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider