May 1, 2000Anesthesia & Analgesia

The Effects of Repeated Doses of Vasopressin or Epinephrine on Ventricular Fibrillation in a Porcine Model of Prolonged Cardiopulmonary Resuscitation

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Why the study?

Does vasopressin improve ventricular fibrillation characteristics and defibrillation success compared to epinephrine in a porcine model of prolonged CPR?

Population

21 pigs in a cardiopulmonary resuscitation (CPR) model after 4 minutes of cardiac arrest

Comparison

Repeated doses of vasopressin vs Repeated doses of epinephrine

Design

Preclinical, Randomly assigned/allocated

Follow-up

1 hour

Authors

UAUlrich AchleitnerUniversität Innsbruck VWVolker WenzelUniversity of Florida HSHans-Ulrich StrohmengerUniversität Innsbruck

Discussion

Member takes

Implication

Vasopressin may preserve VF better than epinephrine in prolonged arrest; leaves open translation to human CPR.

Structured PICO

Does vasopressin improve ventricular fibrillation characteristics and defibrillation success compared to epinephrine in a porcine model of prolonged CPR?

Population

21 pigs in a cardiopulmonary resuscitation (CPR) model after 4 minutes of cardiac arrest

Intervention

Repeated doses of vasopressin (early administration: 0.4, 0.4, and 0.8 units/kg; late administration: 0.4 and 0.8 units/kg)

Comparator

Repeated doses of epinephrine (early administration: 45, 45, and 200 microg/kg; late administration: 45 and 200 microg/kg)

Outcome

Ventricular fibrillation mean frequency and amplitude on defibrillationsurrogate

In a porcine model of prolonged cardiac arrest, vasopressin was superior to epinephrine in maintaining ventricular fibrillation frequency and amplitude, leading to higher rates of successful defibrillation and short-term survival.

Cite This Study

Achleitner et al. (2000) studied this question.

synapsesocial.com/papers/6a1fec227110a651dc04b4e9 https://doi.org/10.1097/00000539-200005000-00012

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