October 7, 2005Stroke
Incidence of Recurrent Subarachnoid Hemorrhage After Clipping for Ruptured Intracranial Aneurysms
Why the study?
What is the incidence of and risk factors for recurrent subarachnoid hemorrhage in patients who regained independence after SAH and had all aneurysms occluded by clipping?
Population
752 patients with subarachnoid hemorrhage admitted between 1985 and 2001, who regained independence and had…
Design
Cohort
Follow-up
mean 8.0 years
Authors
Discussion
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Implication
Elevated recurrence risk after clipped SAH warrants vigilance in follow-up; leaves open targeted prevention for smokers with multiple aneurysms.
Key Points
- This research aims to identify the incidence and risk factors for recurrent subarachnoid hemorrhage (SAH) after aneurysm clipping.
- Analyzed a cohort of 752 patients with SAH from 1985 to 2001 who were discharged to home or rehabilitation.
- Conducted interviews regarding new SAH episodes and retrieved medical records for recurrence verification.
- Employed Kaplan-Meier curves and Cox regression analysis for data assessment.
- Among 752 patients, 18 experienced recurrent SAH, leading to a cumulative incidence of 3.2% over 10 years (95% CI, 1.5% to 4.9%).
- The incidence rate was noted at 286 per 100,000 patient-years (95% CI, 160 to 472).
- Significant risk factors included smoking (HR, 6.5), older age (HR, 0.5), and multiple aneurysms (HR, 5.5).
Structured PICO
What is the incidence of and risk factors for recurrent subarachnoid hemorrhage in patients who regained independence after SAH and had all aneurysms occluded by clipping?
P
Population
752 patients with subarachnoid hemorrhage (SAH) admitted between 1985 and 2001, who regained independence and had all aneurysms occluded by clipping, discharged home or to a rehabilitation facility.
O
Outcome
Incidence of and risk factors for recurrent SAHhard clinical
Patients with successfully clipped ruptured intracranial aneurysms have a significantly higher risk of recurrent SAH within the first 10 years compared to the general population, particularly those who smoke or had multiple aneurysms.
Cite This Study
Wermer et al. (2005) studied this question.