Key result
Nicardipine and verapamil (10(-7) M) enhanced albumin uptake by the media of intact rabbit arteries, and nicardipine reversed K+-induced increases in endothelial permeability.
Why the study?
Does nicardipine or verapamil alter albumin transport across the media in excised rabbit thoracic aorta?
Does nicardipine or verapamil alter albumin transport across the media in excised rabbit thoracic aorta?
Calcium antagonists nicardipine and verapamil enhance albumin uptake in the media of intact rabbit arteries, which may relate to their antiatherogenic effects.
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Hypothesis-generating for antiatherogenic effects of calcium antagonists; leaves open translation to human atherosclerosis.
Tedgui et al. (1987) studied this question. Nicardipine and verapamil vs. Krebs or 80 mM KCl solutions was evaluated on Albumin transport across the media (transmural concentration profiles of 125I-albumin). Nicardipine and verapamil (10(-7) M) enhanced albumin uptake by the media of intact rabbit arteries, and nicardipine reversed K+-induced increases in endothelial permeability.
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