Why the study?
Do calcium antagonists (nicardipine and diltiazem) affect endothelium-dependent relaxation to acetylcholine in rabbit aorta?
Do calcium antagonists (nicardipine and diltiazem) affect endothelium-dependent relaxation to acetylcholine in rabbit aorta?
Nicardipine and diltiazem do not significantly affect the synthesis, release, or relaxant response to endothelium-derived relaxing factor in rabbit aorta.
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Null effect on acetylcholine relaxation in rabbit aorta; leaves open whether calcium antagonists modulate endothelial function in humans.
Jayakody et al. (1987) studied this question.
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