March 1, 1983StrokeOpen Access

Mechanisms of relaxant action of nicardipine, a new Ca++-antagonist, on isolated dog cerebral and mesenteric arteries.

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Population

Isolated dog cerebral and mesenteric arteries (helically-cut strips)

Design

Preclinical

Authors

MYMasahiro YamamotoKumamoto University TOTomio OhtaKyoto University NTNoboru TodaToyama College

Discussion

Member takes

Implication

Hypothesis-generating for selective cerebral effects in stroke models; should not change practice without human data.

Structured PICO

Population

Isolated dog cerebral and mesenteric arteries (helically-cut strips)

Intervention

Nicardipine

Outcome

Arterial relaxation response after contraction with PGF2 alpha, cTxA2, or K+surrogate

Nicardipine produces greater relaxation of cerebral arteries than mesenteric arteries, likely due to greater inhibition of calcium influx and decreased release from intracellular storage sites.

Cite This Study

Yamamoto et al. (1983) studied this question.

synapsesocial.com/papers/6a865c4fda4bf993812ed800 https://doi.org/10.1161/01.str.14.2.270

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Ask AI

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Mechanisms of relaxant action of nicardipine, a new Ca++-antagonist, on isolated dog cerebral and mesenteric arteries.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanisms of relaxant action of nicardipine, a new Ca++-antagonist, on isolated dog cerebral and mesenteric arteries.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider