Why the study?
Do optically pure forms of carvedilol ((R)- and (S)-carvedilol) have stereoselective effects on heart rate, blood pressure, and melatonin release in healthy male volunteers?
Do optically pure forms of carvedilol ((R)- and (S)-carvedilol) have stereoselective effects on heart rate, blood pressure, and melatonin release in healthy male volunteers?
The beta-blocking effects of carvedilol are mediated exclusively by the (S)-enantiomer, while the (R)-enantiomer increases sympathetic tone, likely as a reflex to alpha-blockade.
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(S)-carvedilol mediates beta-blockade during exercise; confirms stereoselective effects and supports enantiopure development.
Stoschitzky et al. (2001) studied this question.
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