Key result
The presence of renal damage in untreated hypertensive patients entailed a 3.3 times higher risk of cardiovascular abnormalities, reclassifying 68% of patients to high-very high risk.
Why the study?
Does the assessment of renal damage improve global cardiovascular risk stratification compared to routine work-up and ultrasonography in non-diabetic, untreated hypertensive patients?
Population
459 non-diabetic, untreated hypertensive patients (64% men, mean age 47.3 years)
Comparison
Assessment of renal damage vs Routine work-up and assessment of left…
Design
Cross-sectional
Authors
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May support renal assessment for risk reclassification in untreated hypertension; leaves open prospective validation beyond cross-sectional data.
Cross-Sectional (n=459)
Does the assessment of renal damage improve global cardiovascular risk stratification compared to routine work-up and ultrasonography in non-diabetic, untreated hypertensive patients?
Relative Risk: 3.3
Assessment of renal abnormalities (microalbuminuria and creatinine clearance) significantly improves cardiovascular risk stratification in untreated hypertensive patients compared to routine work-up and cardiac/vascular ultrasound.
Leoncini et al. (2008) conducted a cross-sectional in Primary hypertension (n=459). Renal damage (creatinine clearance < 60 ml/min per 1.73 m2 or microalbuminuria) vs. Absence of renal damage was evaluated on Cardiovascular abnormalities (3.3 times higher risk). The presence of renal damage in untreated hypertensive patients entailed a 3.3 times higher risk of cardiovascular abnormalities, reclassifying 68% of patients to high-very high risk.
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