Key result
Mild renal dysfunction in primary hypertension was associated with increased risk of left ventricular hypertrophy or carotid atherosclerosis (+43% per SD reduction in creatinine clearance).
Why the study?
Is mild renal dysfunction associated with subclinical cardiovascular organ damage in never previously treated patients with primary hypertension?
Population
358 never previously treated patients with primary hypertension
Comparison
Mild renal dysfunction vs Absence of mild renal dysfunction
Design
Cross-sectional
Authors
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Mild renal dysfunction is strongly associated with subclinical cardiovascular organ damage (left ventricular hypertrophy and carotid atherosclerosis) in untreated primary hypertension, highlighting its utility as a marker for higher cardiovascular risk.
Cross-Sectional (n=358)
Is mild renal dysfunction associated with subclinical cardiovascular organ damage in never previously treated patients with primary hypertension?
Effect estimate: Risk +43% per SD reduction in CrCl; +89% per SD increase in albuminuria
p-value: p=<0.0001
Mild renal dysfunction is strongly associated with subclinical cardiovascular organ damage (left ventricular hypertrophy and carotid atherosclerosis) in untreated primary hypertension, highlighting its utility as a marker for higher cardiovascular risk.
Leoncini et al. (2003) conducted a cross-sectional in Primary hypertension (n=358). Mild renal dysfunction was evaluated on Left ventricular hypertrophy and/or carotid atherosclerosis (Risk +43% per SD reduction in CrCl; +89% per SD increase in albuminuria, p=<0.0001). Mild renal dysfunction in primary hypertension was associated with increased risk of left ventricular hypertrophy or carotid atherosclerosis (+43% per SD reduction in creatinine clearance).
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