Population
Mouse slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles
Comparison
Isometric tetani of varying durations at 20… vs Different durations of tetani and comparison…
Design
Preclinical
Key result
In mouse fast-twitch EDL muscle, but not slow-twitch soleus, the maximum velocity of shortening and unloaded shortening velocity decreased progressively with longer durations of isometric tetanus.
Authors
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Hypothesis-generating for fiber-type differences in tetanic fatigue; leaves open translation to human cardiac or skeletal muscle performance.
In mouse fast-twitch EDL muscle, but not slow-twitch soleus, a maintained tetanus leads to a correlated reduction in the velocity of shortening and the rate of energy utilization, suggesting a decrease in intrinsic cross-bridge turnover rate.
Crow et al. (1983) studied this question. Isometric tetanus duration vs. Different durations (e.g., 3s vs 9s) was evaluated on Velocity of shortening and rate of energy utilization. In mouse fast-twitch EDL muscle, but not slow-twitch soleus, the maximum velocity of shortening and unloaded shortening velocity decreased progressively with longer durations of isometric tetanus.