Key result
Xinmailong injection combined with conventional treatment was the most effective intervention for improving NYHA cardiac functional classification efficiency compared to conventional treatment alone (OR 0.18).
Why the study?
Traditional Chinese medicine injections show effects in HFrEF, but differences in clinical efficacy and safety among various formulations remain difficult for clinicians to identify.
Does the addition of Traditional Chinese medicine injections to conventional treatment improve clinical efficacy and safety in patients with HFrEF?
Population
9,073 HFrEF patients across 107 RCTs
Comparison
6 TCMIs combined with conventional treatment vs conventional treatment alone
Design
Bayesian network meta-analysis of randomized controlled trials
Authors
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Xinmailong addition may improve NYHA class in HFrEF; leaves open confirmation by high-quality RCTs.
Meta-Analysis (n=9,073)
Does the addition of Traditional Chinese medicine injections to conventional treatment improve clinical efficacy and safety in patients with HFrEF?
Odds Ratio: 0.18 (95% CI 0.11–0.31)
The addition of specific Traditional Chinese medicine injections, particularly Xinmailong and Shenmai, to conventional therapy may improve cardiac function and symptoms in patients with HFrEF, though high-quality RCTs are needed for confirmation.
Lin et al. (2021) conducted a meta-analysis in Heart failure with reduced ejection fraction (HFrEF) (n=9,073). Xinmailong injection (XML) plus conventional treatment vs. Conventional treatment alone was evaluated on New York Heart Association (NYHA) cardiac functional classification efficiency (OR 0.18, 95% CI 0.11-0.31). Xinmailong injection combined with conventional treatment was the most effective intervention for improving NYHA cardiac functional classification efficiency compared to conventional treatment alone (OR 0.18).
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