Key result
Serum from patients with primary and secondary hyperlipemia inhibited the clearing activity present in normal serum after intravenous administration of heparin.
Why the study?
Does intravenous heparin cause less lipemia clearing activity in patients with hyperlipemia compared to normal controls?
Population
Patients with primary and secondary hyperlipemia, and normal control subjects
Comparison
Intravenous administration of heparin vs Control subjects (normal serum)
Design
Case-control
Authors
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May indicate serum inhibitors of heparin lipemia clearance in hyperlipemia; hypothesis-generating and leaves open clinical relevance.
Observational
Does intravenous heparin cause less lipemia clearing activity in patients with hyperlipemia compared to normal controls?
Serum from hyperlipemic patients inhibits the lipemia clearing activity induced by intravenous heparin, suggesting a mechanism for impaired lipid clearance in these patients.
Klein et al. (1957) conducted an observational in Primary and secondary hyperlipemia. Hyperlipemic serum vs. Normal serum / control subjects was evaluated on Clearing activity after intravenous administration of heparin. Serum from patients with primary and secondary hyperlipemia inhibited the clearing activity present in normal serum after intravenous administration of heparin.
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