Key result
Microemulsions prepared from the lipids extracted from oxidized low density lipoprotein strongly inhibited the binding of oxidatively damaged red blood cells to mouse peritoneal macrophages by 87%.
Absolute Event Rate: 87% vs 2%
The lipid moiety of oxidized LDL, in addition to its protein moiety, plays a significant role in mediating interactions with macrophage scavenger receptors.
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Oxidized LDL lipids may mediate macrophage binding; leaves open translation to human scavenger receptor biology.
Terpstra et al. (1998) studied this question. OxLDL-lipid microemulsions vs. Native LDL-lipid microemulsions was evaluated on Inhibition of binding of oxidatively damaged red blood cells (OxRBCs) to resident mouse peritoneal macrophages. Microemulsions prepared from the lipids extracted from oxidized low density lipoprotein strongly inhibited the binding of oxidatively damaged red blood cells to mouse peritoneal macrophages by 87%.
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