Key result
Genetic and pharmacological manipulations of epoxylipids reduce cardiac hypertrophy and fibrosis, improve cardiac function, and show therapeutic potential for treating various heart diseases.
Why the study?
Epoxylipids and soluble epoxide hydrolase have been implicated in heart diseases, but a comprehensive synthesis of their contribution and therapeutic potential was needed.
Manipulating epoxylipids and soluble epoxide hydrolase presents a potential therapeutic strategy for treating heart attacks, arrhythmias, and heart failure.
Epoxylipid modulation merits clinical investigation in heart disease; leaves open translation from review data to patient outcomes.
Cardiovascular and heart diseases are leading causes of morbidity and mortality. Coronary artery endothelial and vascular dysfunction, inflammation, and mitochondrial dysfunction contribute to progression of heart diseases such as arrhythmias, congestive heart failure, and heart attacks. Classes of fatty acid epoxylipids and their enzymatic regulation by soluble epoxide hydrolase (sEH) have been implicated in coronary artery dysfunction, inflammation, and mitochondrial dysfunction in heart diseases. Likewise, genetic and pharmacological manipulations of epoxylipids have been demonstrated to have therapeutic benefits for heart diseases. Increasing epoxylipids reduce cardiac hypertrophy and fibrosis and improve cardiac function. Beneficial actions for epoxylipids have been demonstrated in cardiac ischemia reperfusion injury, electrical conductance abnormalities and arrhythmias, and ventricular tachycardia. This review discusses past and recent findings on the contribution of epoxylipids in heart diseases and the potential for their manipulation to treat heart attacks, arrhythmias, ventricular tachycardia, and heart failure.
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Imig et al. (2021) conducted a review in Heart diseases. Epoxylipids and soluble epoxide hydrolase (sEH) manipulation was evaluated. Genetic and pharmacological manipulations of epoxylipids reduce cardiac hypertrophy and fibrosis, improve cardiac function, and show therapeutic potential for treating various heart diseases.
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