Key result
Preoperative diuretic use was associated with a 1.6 times higher total intraoperative phenylephrine requirement during the preclamp period of carotid endarterectomy compared to no diuretic use.
Why the study?
Does preoperative diuretic use increase intraoperative vasopressor requirements in patients undergoing carotid endarterectomy under general anesthesia?
Population
252 patients scheduled for elective carotid endarterectomy (CEA) under general anesthesia
Comparison
Preoperative antihypertensive regimen including… vs Preoperative antihypertensive regimen without…
Design
Cohort
Follow-up
intraoperative
Authors
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May prompt closer BP monitoring in diuretic users; leaves open causality and requires prospective validation.
Observational (n=252)
Does preoperative diuretic use increase intraoperative vasopressor requirements in patients undergoing carotid endarterectomy under general anesthesia?
Effect estimate: 1.6 times
Preoperative diuretic use is associated with increased intraoperative vasopressor requirements to maintain blood pressure before carotid clamping during carotid endarterectomy under general anesthesia.
Anastasian et al. (2011) conducted an observational in Elective carotid endarterectomy (n=252). Diuretics vs. No diuretics was evaluated on Total intraoperative phenylephrine requirement (1.6 times). Preoperative diuretic use was associated with a 1.6 times higher total intraoperative phenylephrine requirement during the preclamp period of carotid endarterectomy compared to no diuretic use.
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