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May 1, 2004Platelets

Emerging roles for P2X1receptors in platelet activation

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Population

Platelets and megakaryocytes (including transgenic animal models)

Design

Review

Authors

MMMartyn P. Mahaut‐SmithFleet Science CenterGTGwen TolhurstUniversity of CambridgeRERichard J. EvansWellington Hospital

Discussion

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Implication

Hypothesis-generating for P2X1 inhibition in arterial thrombosis; prospective trials needed before clinical use.

Structured PICO

P
Population
Platelets and megakaryocytes (including transgenic animal models)
I
Intervention
P2X1 receptor activation and signaling
O
Outcome
Platelet activation and arterial thrombosis

This review highlights the emerging importance of P2X1 receptors in platelet activation and arterial thrombosis, suggesting a potential novel target for antiplatelet therapy.

Cite This Study

Mahaut‐Smith et al. (2004) studied this question.

synapsesocial.com/papers/6a2009a035281a23f90dd46fhttps://doi.org/10.1080/09537100410001682788
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Platelet Membrane Potential in the Initiation of Platelet Aggregation1982 · 78 citations
  2. 2ADP and inositol trisphosphate evoke oscillations of a monovalent cation conductance in rat megakaryocytes1998 · 16 citations
  3. 3Adenosine(5') oligophospho-(5') guanosines and guanosine(5') oligophospho-(5') guanosines in human platelets.1998 · 52 citations
  4. 4Three cation influx currents activated by purinergic receptor stimulation in rat megakaryocytes.1994 · 60 citations