Key result
Combined treatment with captopril-propranolol or losartan-propranolol in hypertensive rats decreased AT1 and ACE expression and increased B1 receptor expression compared to untreated rats.
Why the study?
The effect of single antihypertensive treatments on the mRNA expression of renin-angiotensin system components had been studied, but the effect of combined treatments had not been evaluated.
Does combined antihypertensive therapy (captopril-propranolol or losartan-propranolol) alter the expression of renin-angiotensin and kallikrein-kinin system components in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats
Comparison
Captopril-propranolol or losartan-propranolol vs spontaneously hypertensive control
Design
Preclinical animal study
Authors
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Should not change clinical practice; leaves open translation of combined therapy effects on RAS/KKS expression to human hypertension.
Does combined antihypertensive therapy (captopril-propranolol or losartan-propranolol) alter the expression of renin-angiotensin and kallikrein-kinin system components in spontaneously hypertensive rats?
Combined antihypertensive therapies (captopril or losartan plus propranolol) beneficially alter the expression of renin-angiotensin and kallikrein-kinin system components in hypertensive rats, potentially improving vasodilation.
Lezama‐Martínez et al. (2018) studied Hypertension. Captopril-propranolol or losartan-propranolol vs. Untreated spontaneously hypertensive rats was evaluated on mRNA expression of AT1, AT2, B1, and B2 receptors and ACE and ACE2 enzymes. Combined treatment with captopril-propranolol or losartan-propranolol in hypertensive rats decreased AT1 and ACE expression and increased B1 receptor expression compared to untreated rats.