Population
Preclinical models and general context of hypertension and ageing
Design
Review
Authors
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May not reliably vasodilate via AT2R in hypertension or ageing; leaves open whether reversal alters clinical outcomes.
AT2R stimulation generally exerts vasodilator and antiremodelling effects, but its vascular phenotype may switch from relaxation to contraction in hypertension and ageing, a change reversible by antihypertensive therapy.
Widdop et al. (2008) studied this question.
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