Key result
In guinea-pig myocardium, atrial cells have a lower Na+ pump density than ventricular cells, resulting in higher intracellular Na+ activity and greater sensitivity to Na+ pump inhibition by dihydroouabain.
Guinea-pig atrial cells have a lower Na+ pump density than ventricular cells, leading to higher intracellular Na+ activity and greater sensitivity to Na+ pump inhibition.
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Guinea-pig atrial Na+ findings require human validation before any clinical inference; leaves open species differences in pump regulation.
Wang et al. (1993) studied this question. Dihydroouabain (DHO) vs. Papillary muscle / Baseline was evaluated on Intracellular Na+ activity (aNai) and membrane resting potential. In guinea-pig myocardium, atrial cells have a lower Na+ pump density than ventricular cells, resulting in higher intracellular Na+ activity and greater sensitivity to Na+ pump inhibition by dihydroouabain.
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